Since mice vaccinated with control DNA had all died after HK/156 challenge, a group of naïve animals was added to the HK/483 challenge to confirm lethality of the challenge dose.
Sixty asthmatic patients with a history of AERD completed a double-blind placebo controlled challenge with 100 and 200 mg of celecoxib over 2 days, followed by an aspirin challenge to confirm the clinical history.
Eighty-eight (92%) of all participants underwent a standardized oral food challenge to confirm their allergy; the 8 children who had severe anaphylaxis and needed epinephrine did not have the challenge.
A retrospective study reported a challenge to confirm the diagnosis of radiation pneumonitis in 48% of cases due to presence of the confounding factors such as exacerbation of chronic airway disease, chest infection, and tumor progression [ 28].
The organization of that network has long remained a bone of contention among materials experts, as concrete's structure has proven challenging to confirm with traditional tools, such as x-ray, electron, and neutron scattering.
Therefore, the results shown in Figs. 7 and 9 clearly demonstrate the detection of early-stage dysplasia with pinpoint accuracy, which is challenging to confirm with most imaging modalities, by obtaining stimuli-triggered, multimodal (scattering and Doppler variance) optical signal changes using novel nanoparticle-based optical contrast agents.
More precisely, in order to validate our model beyond the correlation of measured and predicted values, pRC was challenged to confirm well-known correlations of RC with drug resistance, number of treatment lines, and treatment interruptions.
In addition, samples were collected at 12, 20, 24, 30, and 36 h post-challenge to confirm infection by quantifying bacterial and SCC concentrations.
Clinically, it was challenging to confirm VA in cases 12, 13, 15, and 16, because no definite pale optic discs were noted.
However, it is sometimes challenging to confirm the diagnosis in children who lack any of the known mutations, because clinical and laboratory findings of JMML can be mimicked by other diseases, such as viral infections.
The challenge is to confirm the associations between the processes of care identified in these narratives with both short- and long-term outcomes in the health of women and their families.
