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This approach has the potential i) to provide a global profiling of the modulated genes at this first measurable phenotypic checkpoint in T1D pathogenesis, ii) to allow novel hypothesis to be formulated concerning the initiation of the islet-destructive autoimmune process and eventually to further challenge these hypothesis.
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Multiple lines of evidence either supporting or challenging these hypotheses have been alternatively reported, which evidences the difficulties emerging while studying mechanisms of brain development across evolution.
To challenge these two hypotheses, we selected 132 Xanthomonas axonopodis strains representative of 18 different pathovars which display different host range.
Therefore, it appears that appropriate structures are available to challenge these two hypotheses via MD.
To challenge these two hypotheses, we tested the ability of ZOL to prevent GGPP incorporation into substrate proteins in vitro and in vivo.
These findings challenge the hypothesis that the failure of extensively cultivated BCG vaccines to prevent pulmonary tuberculosis is due to over-attenuation and suggest instead a new model in which BCG evolved to produce more immunity-suppressing antioxidants.
These results challenge the hypothesis of a universal role for tubulin isotypes in tumor growth and the development of drug resistance.
These results challenge the hypothesis that GlcNAc is a perfectly rigid C1 chair, as predicted by high-level energy calculations without explicit water, straightforward interpretation of NMR data and non-equilibrium nanosecond-simulations.
These convergent findings challenge the hypothesis that CDs formed naturally and suggest that they area instead anthropogenic.
These data strongly challenge the hypothesis that CLIC4 potentiates TGFβ signaling in the kidney following acute injury.
Most sports sociologists, however, challenge this hypothesis and believe instead that research confirms that violence and aggression are socially learned.
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CEO of Professional Science Editing for Scientists @ prosciediting.com