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The agency further admitted it was under "immediate financial pressures" and said Trafigura would probably "take any and every procedural opportunity to challenge steps taken in a further investigation", which would extensively increase the costs.
DTH-arthritis was induced by eliciting a classical DTH reaction in one paw with methylated bovine serum albumin (mBSA), with the modification that a cocktail of type II collagen monoclonal antibodies was administered between the immunisation and challenge steps.
The simplest interpretation is that the oral exposure primes a cell population that does not become active effector at this step, but becomes so by further encountering the same antigen at the sensitization and challenge steps.
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Using a larger volume of inoculum may lead to biofilm formation high on the peg that physically escapes exposure in this challenge step.
When you're in the midst of a serious health challenge, step back and start to ask 'what is this trying to tell me".
This involves several challenging steps, from cleaning to concept tagging.
France has talked about other new sanctions that could hinder the sale of petroleum industry equipment and technology to Iran, but it has hardly challenged steps backing away from the sanctions involving gasoline it once believed would work.
The construction of a large supermatrix involves a number of computationally challenging steps including, but not limited to, database operations, BLAST comparisons, sequence clustering, multiple sequence alignment, and combining data sets.
An essential, but challenging step is the functional analysis of the resultant phenotype.
How to select appropriate polymer materials in a vast parameter space is a critical but also challenging step.
To meet these challenges, STEP-BD uses a hybrid design to collect longitudinal data as patients make transitions between naturalistic studies and randomized clinical trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com