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Large-scale Taliban assaults, involving several dozen fighters, are not unprecedented and indicate the extent of the challenge posed to the embattled security forces.
One veteran republican dissident from Derry who spoke to the Guardian this week succinctly summed up the challenge posed to Sinn Féin: The thing to watch are the numbers.
And the removal of Peter Dolan from the top job at Bristol-Myers Squibb BMSS) this week came as a result of his mishandling of a challenge posed to Plavix, the company's lucrative blood-thinning drug, by a generic rival.
A major item on the agenda of the Council of Constance was the challenge posed to the authority of both contending parties, council as well as pope, by the teachings of the Czech preacher Jan Hus.
Mas is wide awake to the challenge posed to French producers by upstart new world winemakers, recounting how, in the noughties, "Australia and Chile came in and kicked us out of the market".
The new film will focus on the challenge posed to Blair by George W Bush's, ahem, victory in the 2000 US election and the PM's fateful decision to heave the whole weight of his then-credible premiership behind a man widely considered to be politically naïve and dangerous, not to mention illegitimate.
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Because we are acutely aware of the existential threat that this global challenge poses to our way of life in Small Island Developing States the world over.
Rapid change is required in order to address the fresh challenges posed to humans in the 21st century.
But one of the biggest challenges posed to this new and growing market is finding qualified workers.
Mark Everson, the IRS Commissioner, told a group of senators last August that the challenges posed to the agency by transfer-pricing manipulation "are acute and ever growing.
This chapter also suggests effective ways to tackle the challenges posed to students by these four key features.
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