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For one of the reactors tested, biodosimetry tests were conducted with two challenge organisms that had different UV dose response behavior; UV dose distribution estimates from LA yielded predictions of microbial inactivation that were in agreement with measured inactivation responses for both challenge organisms for all test conditions.
It is likely that the agreement between LA results and biodosimetry data was related, in part, to the agreement between the action spectra of the microspheres and the challenge organisms.
When combined with the UV254 dose response behavior for challenge organisms used in simultaneous or parallel biodosimetry experiments, the dose distribution estimates developed from the microspheres yielded estimates of challenge organism inactivation that were in agreement with measured values.
In the sleeve unit, the removal performance improved for MS2 virus between V1 and V2 but decreased for all other challenge organisms.
The early time points, which assess the rate of kill of the challenge organisms, revealed the most significant differences between the two preservative systems.
All other microbes showed average reduction values for the challenge organisms at least 2 lower lower as compared with those seen from conditioned biofilter units.
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induces tissue damage in the lungs, thus limiting the ability to subsequently clear large doses of the challenge organism.
Interestingly, following differential plating on YPD media with and without nourseothricin (a selectable marker for the H99γ strain), colonization of spleen and brain was due to the challenge organism, strain H99, while the colonization of the lungs was due to the immunizing organism, strain H99γ.
A 1 10 dilution of each hand rub was produced by adding 1 ml of the challenge organism suspension to 9 g of the hand rub.
Micrococcus luteus (Fleming strain) was grown in tryptic soy broth (TSB) at 30°C and was used as a challenge organism for the detection of antibiotic activity.
All 18 challenged subjects had positive stool cultures for the wild-type challenge organism, and all 6 controls had positive jejunal fluid cultures (with a mean of 7 × 10 CFU/mL).
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