Aging pop stars must navigate the challenge of maintaining relevance while avoiding desperation.
Understanding this system is a fascinating challenge of critical relevance for biology and medicine, since misexpression or mutation of multiple PcG components, as well as of TrxG members of the COMPASS family and of the SWI/SNF complex, is implicated in cancer and other diseases.
In the line of therapy, designing effective deep brain stimulators to suppress the pathological synchrony among neuronal ensembles is a challenge of high clinical relevance.
The lack of an experimental tradition in glacial geomorphology leaves many research avenues open for exploration but also increases the challenge of demonstrating the relevance of experimental results to theoretical and field-based studies.
Given the state of publishing in Africa, the challenge of elevating the relevance and usefulness of the continent's medical/health journals is enormous.
The results of their study posed a challenge to the relevance of mesothelial cells as a source of peritoneal myofibroblasts.
But maybe, just maybe, with Alvarez out of action, Bellator and Viacom can truly appraise the value of their five-year-old promotion and challenge the relevance of the Pay Per View model altogether.
Even the past and present opponents to the Cell Theory seem to agree with the atomistic idea, as their arguments challenge the relevance of the Cell as the unit of life, but not the existence of a "unit" itself [ 258].
These discrepancies of in vivo and in vitro data presumably reflect the requirement of considerably elevated local NOD1 CARD concentrations and challenge the relevance of CARD-mediated homodimer formation in vivo, in particular as endogenous NOD1 levels are thought to be very low.
In conclusion, our results challenge the relevance of the ADI, because it is calculated today from the toxicity of the AP alone in vivo.
I added that it was particularly important to challenge the relevance of "instrumental arguments" about funding; even more so to insist on the "intrinsic importance of values as a key justification" for arts support.
