Although many genetic inhibitors have been demonstrated to mediate potent inhibition of HIV-1 replication [9] [12], inhibition of viral replication has generally been evaluated using in vitro conditions in which >95% of cells express the inhibitor under study, a highly artificial setting given the challenges of attaining levels of even 5% to 10% genetically-modified CD4+ T cells in vivo.
The challenges of attaining accelerated and sustainable growth and food security have been, and will likely continue to be, exacerbated by global climate change and extreme weather fluctuations.
From the examination of algorithm performance and contributing factors affecting the observed discrepancies, this study provides insight into the challenges of attaining and maintaining quality data in primary care EMR databases.
Based on our experiences of conducting a range of case studies, we reflect on when to consider using this approach, discuss the key steps involved and illustrate, with examples, some of the practical challenges of attaining an in-depth understanding of a 'case' as an integrated whole.
Here was a batsman, whose mind was totally at ease, stimulated by the challenge of England attaining their highest winning score at Old Trafford.
Yet despite recent improvements in global lipidomics capabilities driven by MS, a number of significant analytical challenges stand in the way of attaining truly 'global' or comprehensive characterization of the lipidome.
In looking at the possible outcomes of tomorrow's election ― and yes, both will provide challenges for attaining broader rights, just different ones ― let's take the reality of a President Trump first.
Campbell's central argument, that all mythological tales spring from a single monomyth in which a hero defeats a series of challenges to attain a life-changing gift, is central to both video game and movie structure.
Jared Leto can only dream of attaining Sydney's vibe!
