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While point-and-click enthusiasts may notice a reduced level of obtuse brain-twisters that defined the genre's popularity in the 90s, the level of challenge is adequate enough and the simple interface and inventory system help to reinforce a tone that steadily wavers between emotional poignancy and quirky, light-hearted comedy.
The most significant challenge is adequate monitoring of springs that are quickly affected by surface events, such as rain events, and adjustment of treatment plant operations to remove new constituents or continue control of increased levels of those already present.
That challenge is adequate margins on the partial mastectomy specimen.
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The study warned that the challenges are "adequate and sustainable training", but recommended that the technique should be considered for "careful implementation" where a shortage of healthcare human resources threatens programmes.
RCTs depend entirely on volunteering participants, and therefore one of the main challenges facing RCTs is adequate recruitment [ 2, 3].
Another challenge is building adequate enrollment.
I think that the scientific challenge of stockpile stewardship is adequate to that task, and I believe that can be done without new weapons.
In a previous study we observed that a fluid challenge of 4 ml/Kg is adequate to raise the mean systemic filling pressure (Pmsf) and to increase venous return in fluid responsive patients.
A key challenge to their structure determination is adequate protein expression.
A major challenge during endoscopic transsphenoidal surgery is adequate intraoperative hemostasis.
"Greed is adequate"?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com