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Guiding early therapeutic decisions represents an important challenge in the treatment of patients with cholangiocarcinoma.
Resistance to chemotherapy is a major challenge in the treatment of ovarian/peritoneal cancer.
Delivering therapeutic agents to the brain is a major challenge in the treatment of most brain disorders.
The spread of cancer cells to distant organs represents a major clinical challenge in the treatment of cancer.
Recurrence following primary platinum-based chemotherapy remains a challenge in the treatment of patients with advanced-stage epithelial ovarian cancer.
Resistance to the HER2-targeted antibody trastuzumab remains to be a major clinical challenge in the treatment of HER2-positive breast cancer.
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Likewise, drug resistance in T. brucei gambiense and T. brucei rhodesiense has raised significant challenges in the treatment of sleeping sickness.
Thus, there could be challenges in the treatment of infections associated with organism.
Despite evolution of new antidepressant treatment, clinicians still encounter challenges in the treatment of depressed patients.
Thus, early detection and inhibition of metastasis remain among the greatest challenges in the treatment of these tumors.
Development of multidrug resistance and toxicity associated with higher doses, poses significant challenges in the treatment of hepatic cancer using DOX.
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