Some informants feared that the limited involvement of existing district level monitoring and evaluation systems that document programme outcomes would result in challenges in observing the effect of CHAs' work.
JUSTICE SCALIA is certainly correct in observing that challenges founded upon these provisions are reviewed under different standards.
In line with the rapid rise in temperature after challenge observed in the prophylaxis experiment ferrets treated with CR6261 24 hours after challenge showed a mean maximal temperature of 41.5°C before CR6261 was administered (p = 0.15 versus 41.8°C of the control group, figure 2C).
Additionally, MCHAtax mice were unable to consolidate SWS and increase slow-wave activity (SWA) in response to this homeostatic challenge as observed in MCHWT littermates.
The dysregulation of innate immunity in SAA patients may result in increased proinflammatory cytokine production towards bacterial challenge as observed in IRAK3-/ mice [ 36].
Furthermore, CCM hearts demonstrated a loss of circadian rhythms in metabolic and functional responses to a workload challenge normally observed in wild-type hearts ex vivo.
Nonetheless, when 3 immunizing doses were used, as was the case in the investigations reported here, full protection against sporozoite challenge was observed in the mice made tolerant to the CSP, thus casting a doubt on a central role for CSP in sterile immunity.
In contrast, significant decrease of AMPs mRNA expression after Vibrio challenge was observed in crustin, mytilin B and penaeidin, respectively [19], [20], [21], [22], [23].
The protective effect of oral vaccines upon WSSV challenge was observed in Macrobrachium nipponense.
