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Vaccination was safe and well-tolerated and elicited protection from challenge in approximately 50% of subjects, providing the first proof-of-principle of a DNA vaccine affording protection in humans.
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The issue of perspective has emerged as an important methodological challenge in this review: approximately half the studies in this review took a provider or health service perspective.
Breast cancer remains a major public health challenge in the United States, with approximately 215,990 new cases among women and 40,000 deaths projected for 2006 [ 1].
Among those who completed pre-Challenge and formally enrolled in ChalleNGe, approximately 78%% graduated from the program.
Interestingly, endotoxin challenge in mice resulted in elevated (approximately five-fold) circulating levels of sFlt-1.
2 7 The burden of RHD is still a major challenge in the developing world with approximately 345 000 deaths per year worldwide.
For systemic inflammation, only half of the control group mice survived at 26 h after LPS challenge, but approximately 75% of mice in the HSOE group were alive at the same time point.
Symptomatic recurrence of Clostridium difficile infection (CDI) occurs in approximately 20% of patients and is challenging to treat.
In volume recording experiments, we found hypertonic challenge first led to shrinkage, but that within 20 min, volume recovered in approximately 50% of cells.
Transmitted drug-resistant (TDR) HIV is an ongoing public health challenge, affecting approximately 7 21% of new HIV infections in the United States and Europe [1] [6].
In intensive care units (ICUs), a fluid challenge based on clinical criteria leads to a significant increase in cardiac output (CO) in approximately 50% of patients [ 1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com