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It's a major challenge given obstacles surrounding oxygen and nutrient supply to the tissue.
Training the valvemen continues to be a challenge, given many are poorly paid and undereducated.
Running RSA will be a challenge, given the recent discovery of problems at its Irish division.
Adrienne McAlpine, 41, said she found dating a challenge, given her living situation at Cutter House.
Fund-raising is bound to be a challenge, given the tough economic climate.
He was well suited to the challenge, given his well-tuned empathy.
For promoted tweets, this is hardly a challenge, given the 140-character limit.
It posed an interesting challenge, given the reams of data to examine.
Nationalizing Citigroup outright would be a huge challenge, given the company's size and international sweep.
This could be a challenge given the coming change of leadership in Beijing.
Biomimetic design in cartilage tissue engineering is a challenge given the complexity of the native tissue.
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