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Although our analysis is limited to these disease model examples, the challenge approach is generally applicable to the vast majority of pharmacological intervention studies.
Furthermore, this repetitive challenge approach allowed us to calculate per-exposure probability of infection, an observed vaccine efficacy of 64%, and undertake a systematic analysis for correlates of protection based on exposures needed to achieve infection.
Dementia care qualifies as exactly the type of issue that requires the concentrated effort called for in a Grand Challenge approach.
From this study, Salmonella Typhi challenge appears to fall into the latter category, the features of which are seen as desirable prerequisites for using a human challenge approach to assess vaccine and therapeutic efficacy.
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Monksland was not at ease on the heavy ground and Carberry sat well off a strong pace set by Whatuthink before delivering his challenge approaching the final flight.
The final days of my challenge approached and I was still going at it, hitting the 1,000 competitions mark.
The final days of my challenge approached and I was still going at it, hitting the thousand competitions mark.
One promising, yet challenging, approach is to measure and model the atmospheric composition in remote regions.
United commonly have greater prizes in mind than that or the Carling Cup but today's victory is a fillip as the true challenges approach.
In the larger context, IBM Research Africa's "solving grand challenges" approach could be a harbinger for bigger changes on the continent.
Trump has taken that factually challenged approach from the campaign trail directly into the Oval Office.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com