We have presented in vivo evidence to suggest that the majority of infected DCs recovered from the skin immediately after L. major challenge acquire their infections via capture of infected neutrophils, and that these encounters are responsible for inhibiting DC activation and their ability to initiate the anti- Leishmania T-cell response.
The company is an example of a complex business that can face significant challenges acquiring and retaining customers, as well as one that faces an existential threat from Amazon.
Although they address distinct aspects of treatment-associated challenges (acquired resistance and oncogenic side effects), they both relate to the less appreciated issue of treatment scheduling.
These spacer sequences are known bacterial defense mechanisms against viral and plasmid challenges acquired from foreign invading DNA, with the number of new phage-derived spacers being correlated with phage resistance [ 16].
In addition, we waited 3 minutes after each challenge, ventilating the dogs with the same normal tidal volume breaths as used after the local catheter challenge, before acquiring the first set of scans at FRC.
BT surprised analysts last year when it moved aggressively to challenge Sky, acquiring the rights to 38 matches a season over the next three years, beginning with the 2012-13 season.
I'm a literary critic and historian by training and inclination, but I enjoyed the challenge of acquiring new kinds of knowledge in researching this book.
But the active death penalty states – which now number less than 10 – still face the challenge of acquiring lethal injection drugs in the face of a worldwide boycott of sales to US corrections departments.
Companies that spot disruptive developments early can meet the challenge of acquiring legitimately disruptive, high-growth companies at reasonable prices, before the market recognizes its disruptive potential.
However, the huge discrepancy in the mechanical and chemical properties of different components poses a great challenge in acquiring a stable interface that can survive large strains (>100 %) [73].
