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Chains of active, often explosive volcanoes are thus formed in such places as the western Pacific and the west coasts of the Americas.
Chains of active volcanoes, such as those occurring at island arcs, are commonly marked by individual high mountains separated by large expanses of low and gentle topography.
Firmly gripped by the tidal pull of its parent planet's gravity, yet yanked the other way by the shifting gravitational fields of two of its three sister moons, Io produces seemingly endless chains of active volcanoes.
All compounds bind in the same orientation as reaction product β- d-galactose, forming similar hydrogen bonding interactions between ligand 3-OH, 4-OH and 6-OH substituents, and side chains of active site residues W135, G48, T93, S261 and R380.
The other terminal hydroxyl group of WA is also involved in forming H-bonds with SER740 and ASP738 of chain A. NEMO and IKKβ chains of active NEMO/IKKβ complex are held together by strong intermolecular hydrophobic interactions between LEU93 PHE734, THR735 PHE92, PHE734 MET94, TRP739 PHE97, TRP741 ALA100, TRP741 ARG101.
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However, the pharmacology and the toxicology as well of these drugs remain complex due to a chain of active metabolites with a final pathway frequently involving nordiazepam and oxazepam.
Submarine mountains had been discovered in the middle of the Atlantic Ocean, but the extent of the mid-ocean ridges, as they are now called, only became apparent from echo-sounding measurements made after that war: Now it is known that the global system of mid-ocean ridges encircles the Earth, like the stitching on a baseball, and forms a global chain of active volcanoes.
In addition, HeLa cells manifested the proteolytic maturation of caspase-3, as indicated by the progressive degradation of the inactive pro-caspase-3 in parallel with the accumulation of a ∼17 kDa fragment corresponding to the heavy chain of active caspase-3 (Fig. 1(d)).
For each target, the center of the boxes and their dimensions were defined manually in order to include in the outer box all the side chains of the active site as defined above.
The Tyr interaction was only available following local rearrangement of the side chains of the active site because of inhibitor binding.
Our crystal structures show that the carboxylate side chains of the active site aspartic acid triad coordinate two divalent metal ions.
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