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Compound 32 was modeled into the β-tubulin paclitaxel-binding site and shown to be able to adopt a conformation similar to T-taxol with the C-4 and C-13 side chains matching closely.
(214) In a bilayer composed of a lipid mixture, the lipids with the lengths of the fatty acid chains matching the dimensions of the hydrophobic exteriors of integral proteins concentrate around the proteins, to minimize hydrophobic mismatch.
That is, for further searches with hmmsearch using the model's trusted or noise cutoffs, we can use PoSSuMsearch2 using cutoff π tc or π nc as a filter and apply the compute intensive hmmsearch only on sequences that contain chains matching to the PSSM-FM.
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The 1,3-methylene group distance, 0.251 nm, of all-trans alkyl chains matches the distance of the next nearest neighbor of the HOPG lattice, 0.246 nm, along, e.g., the [11 2 ¯ 0] crystallographic direction.
Compounds 1aaa, 1bca, 1acd, 1ace and 1adc contain a selection of side chains matched and mismatched to the sequence of p53 (naphthyl acting as a mimetic of indole).
Although the resolution was too poor for any detailed interpretation of individual side chains in most regions, in the best regions of the maps the pattern of large and small side chains matched that in the locked form, though de novo identification would have been impossible.
Recently, we studied transgenic C57Bl/6 mice ("NSE-Db" mice) which have a neuron-specific enolase promoter driving the expression of a full-length Db heavy chain (matching their endogenous H-2D allele) specifically in their CNS neurons [18], [19].
XRD demonstrates the mixed carbon chain matched with the carbon chain distribution of saturated hydrocarbon have better ability than the single on inserting into the wax crystal.
After a series of events between Dutt and Lethal, TNA began to promote a Black Tie Brawl and Chain match between the two at Hard Justice.
Lethal and Dutt then had a standard wrestling match at Victory Road; which Dutt won; and a Black Tie Brawl and Chain match at Hard Justice; in which Lethal was victorious.
In accordance with the single residue mutation, the Trp95Leu mutant crystal structure is very similar to that of wild-type β2-m (R.S.M.D. 0.55 Å, calculated over 97 Cα pairs), and the mutated Leu95 side chain matches the location of the Trp95 indole ring in the wild-type protein.
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