Modeling and evaluating the performance of such large systems typically require the solution of queueing network models with large numbers of chains (classes), service centers, and populations.
In addition, there are two basic kinds of L chains, called lambda and kappa chains, either of which can be associated with any of the H chain classes, thereby increasing still further the enormous diversity of immunoglobulins.
Sharomi and Gumel developed mathematical models by introducing mild and chain classes [12].
There are five human heavy-chain classes (IgM, IgG, IgA, IgE, and IgD) and two light-chain classes (lambda and kappa).
In some cases, all human immunoglobulin genes have been inserted, including all heavy-chain classes [ 27].
This is because the unfavorable interaction with the hydrophobic class of side chains is offset by the favorable interaction between sarcosine and the polar and charged side chain classes of residues.
There are five Ig isotypes present in mammals, which are defined by their heavy chain constant region (A, D, G, E, M) and there are two light chain classes seen in vertebrates (λ and κ) [ 28].
A positive correlation was observed between longevity and the abundance of short-chain saturated fatty acids C14 0, C16:0 and C15 -iso, a trend that was reversed for the longer-chain classes 18 0, 20 0 and 22 0.
Lymph nodes from 21 patients with non-Hodgkin's lymphomas were phenotyped as cell suspensions for PNL binding, and the following surface markers: E rosetting, C3d, SIg, OK markers of T-cell subsets, Ig heavy-chain and light-chain classes.
DNA segments from the JH-Sμ region and from the region 3′ of Cα are normally present in the functional IgH gene of all hybridomas, regardless of the heavy chain class which is expressed.
Finite order Markov chain class (finite source memory).
