Sentence examples for chain surrogate from inspiring English sources
To improve our understanding of GM-CSFRα inhibition a mouse GM-CSFR chain surrogate antibody CAM-30033) was developed for in vivo pharmacology, as the clinical antibody mavrilimumab does not cross-react with rodents.
A library of paclitaxel (taxol) mimics was obtained by a straightforward strategy involving rational design and an efficient synthesis of a simplified taxane core substitute, together with a click-chemistry combinatorial search for phenylisoserine side-chain surrogates.
The mIgM molecule of pre-BCRs is composed of IgM heavy chains and a surrogate light chain.
The dysregulated expression of cytokines and costimulatory molecules explains the reported accumulation in one-third of RA samples of an unusual subpopulation of peripheral B cells with a restricted immunoglobulin variable region gene repertoire that coexpress conventional light chains and the surrogate light chain of pre-B cells [ 58].
The cells used were the BLIN-1 pre-B cell line expressing low levels of cell surface mu heavy chain associated with surrogate light chain and the 1E8 immature B cell line expressing cell surface mu/kappa.
The upregulation of Prr14 was confirmed at the protein level, which co-related with the induction of myosin heavy chain (MHC), a surrogate marker of the skeletal muscle differentiation.
Consistent with these findings, free light chains as a surrogate marker for plasma cell activation were only influenced significantly by treatment with MMF but not with CYC.
Unlike heterotetrameric canonical antibodies that are composed of identical pairs of heavy and light chains, the pre-BCR is a heterohexameric complex composed of identical pairs of heavy chains that are each paired with a two-subunit surrogate light chain (SLC).
After a productive V(D J recombination, the cytoplasmic μ heavy chains (c μHCs) are expressed and then paired with surrogate L chains (VpreB and λ5 proteins) to form the pre-B-cell receptor (BCR) at the pre-B-cell stage.
Significant E2A binding was detected at the promoters and enhancers of several essential B-lineage genes, including the Igkappa intronic and 3' enhancers, lambda5 and VpreB surrogate light chain promoters, the EBF locus promoter region, and the mb-1 (Igalpha) promoter.
