Sentence examples for chain pairings from inspiring English sources

Heavy and light chain pairings resulted in 48 antibodies from 43 distinct wells that expressed detectable IgG by ELISA (data not shown).

Mathematically, this strategy allows for ~6,000 possible heavy chain (subscript H ) and ~300 possible light chain (subscript L ) V(D J combinations, for a total of ~1.8 million possible heavy-and-light chain pairings [ 2, 3].

Unlike antibody display technology, our method enables the preservation of original heavy-light chain pairings, which is useful in analyzing protective antibodies in infectious disease or identifying autoimmune antibodies in humans.

Key advantages of this approach include a large repertoire of potential human heavy and light chain pairings, efficient flow cytometric enrichment, eukaryotic-type post-translational modifications, absence of potential xenoreactive sequences and efficient conversion to soluble secreted scFv for validation [ 20].

The abundance of heavy- and light-chain pairings that were observed in the unselected libraries and within selected antibodies are illustrated in Figure  4 for VH-Vλ combinations and in Figure  5 for VH-Vκ combinations.

The completed library thus contained combinatorial pairings of naïve H and L chains as well as sets of synthetically randomised H chains paired with natural chicken L chains.

However, chains of specification/artifact pairings, positioned at varying degrees of abstraction, are governed by different notions of correctness.

Standard theories suggest that the first informational replicator involved RNA molecules (or a more primitive analogue) and that a preliminary step for the development of such replicating systems may have been the emergence of subunits capable of forming chains and interchain pairings.

The fact that minor perturbation of final insulin structure caused by G(B23)V substitution is greatly outweighed by major defects in the ability to assemble the insulin chains with proper cysteine pairings indicates that this MIDY mutant is blocked primarily in the protein folding pathway rather than in the stability of the insulin native state.

We assume that a molecule folds in a configuration that stabilizes its backbone and side chains through various base pairings.

To understand this, we studied the elastic property of ssDNA through the Monte Carlo implementation of a modified freely jointed chain (FJC), with electrostatic, base-pairing, and base-pair stacking interactions all incorporated.