A synthetic method has been designed to produce alkylphosphatidylcholine lipid molecules with the fluorescent group all-(E -1,6-diphenyl-1,3,5-hexatriene (DPH) incorporatE -1,6-diphenyl-1,3,5-hexatriene chain of variablE -1,6-diphenyl-1,3,5-hexatriene
This paper presents the electrochemical recognition properties of a series of redox-active ionophores containing two distinct complexing cavities: a Schiff base ligand complexed with NiII, CuII or FeIII and locked by a flexible polyoxyethylene chain of variable size.
We designed, prepared and tested a set of structural analogs 1 4 as new hybrid compounds by incorporating, through a common alkyl chain of variable length, the pharmacophoric elements of N-n-alkyl nicotinium salts (non-α7 nicotinic acetylcholine receptors antagonists) and of 7-hydroxy-2- aminomethyl chromanes (dopaminergic D2 receptor agonists).
The design, synthesis and biological evaluation of novel pyrrolo [2,1][1,4] benzodiazepine (PBD) dimers 38 43 linked with pyrrole and imidazole polyamides from either side by a flexible methylene chain of variable length are described, which involved mercuric chloride mediated cyclization of the corresponding amino diethyl thioacetals.
In a continuing search for potent P-gp-dependent multidrug-resistant (MDR) reversers we synthesized and studied a new series of N-alkanol-N-cyclohexanol amine aryl esters characterized by the presence of two linkers with different flexibility: a polymethylene chain of variable length and a cyclohexylic scaffold, that gave origin to two geometrical isomers (cis and trans).
Gangliosides are amphiphilic molecules consisting of an oligosaccharidic chain of variable length and complexity bound to a ceramide anchor.
Gangliosides are amphipathic molecules composed of a ceramide lipid anchor attached to an externally oriented oligosaccharide chain of variable length and complexity.
As an added design feature, a chain of variable length separated the trimethylammonium group from the reactive methanethiosulfonate group as a means of controlling the access of the reactive group to Cys289 or other nucleophiles.
Findings are therefore more accurately described as a "sequence" or chain of variable initiating events all manifesting the clinical phenotype of autism.
Vitamin K 2 consists of a group of menaquinones, which are characterized by the length of their isoprenoid side chain, a lipophilic, polyunsaturated side chain of variable length (Fig. 2 ).
