Indeed, the entire S-RNase main-chain frame works superimposes well with T2- RNases, in particular the core structures composed of three α-helices and four β- strands.
COL4A3: Missense variants (~45% of the variants, 85% of which are glycine substitutions in the conserved Gly-Xaa-Yaa repeat sequence in the collagenous domain of the alpha3(IV -chain); frame shIV -chainll deletions, small insertions/duplications) (~20%); nonsense variants (~15%); splice site variants (~15%) and larger deletions.
COL4A4: Missense variants (~50% of the variants, 75% of which are glycine substitutions in the conserved Gly-Xaa-Yaa repeat sequence in the collagenous domain of the alpha4(IV -chain); frame shIV -chainll deletions, small insertions/duplications) (~27%); splice site variants (~13%); nonsense variants (~9%) and larger deletions.
The granite facade is simply marked "prison" and embellished by two identical reliefs, a circle of chains framing a pair of crossed keys.
Producers embedded in supply chains framed in the context of a captive governance face tight relationships that may ensure market access in the short run but do not provide any stable operating framework and give them no voice in the shaping of the relationships and in the targeting of the chain product(s).
Singer Neil Tennant, he of the sturdy tenor singing lyrics of being "chained, framed -- you know what I mean" in "One More Chance," grooved in a barbed black jacket with porcupine-like needles jutting out in all directions.
The variations on upcycling are endless – from clutch bags made from bottle caps to bicycle chain mirror frames.
David Ward from Giant Bikes talked me through chain sets, frames and cranks until my head was spinning.
Two days later, the visitor chained his frame to a lamppost on St. Mark's Place, then returned 20 minutes later to find that the wheels had vanished.
Unique restriction sites were introduced to allow for insertion of the variable regions of the heavy and light chains in frame with the constant regions.
