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The crystal structure of the bovine factor Va molecule lacking the entire A2 domain and the acidic COOH terminus of the heavy chain (factor Vai) has been determined (18).
As shown in Figure 3, following incubation with thrombin no single chain factor V was apparent on the gels (most obvious in panel C, lane 2), while fragments with the expected molecular weights representing the heavy and light chain of the cofactor appeared.
To ascertain the function of these regions, we have created a mutant recombinant factor V molecule that is missing the last 30 amino acids from the heavy chain (factor VΔ680−709) and a mutant molecule with the DYDY → AAAA substitutions (factor V4A).
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The principle aim of this paper is to empirically investigate the relationship between supply chain factors and the adoption of e-Collaboration tools in the supply chain of Electrical and Electronic (E&E) organizations in Malaysia.
In this paper, we investigate how this class of variability, chaos, may occur in a multi-level supply chain and offer insights into how to manage relevant supply chain factors to eliminate or reduce system chaos.
The basic theory of technology adoption suggests that household (e.g., income, attitudes) and institutional (e.g., information campaigns, supply chain) factors determine household choice (Pattanayak and Pfaff 2009).
6 The Improving Supply Chains for Community Case Management of Pneumonia and Other Common Diseases of Childhood Project (SC4CCM) was created to identify supply chain factors that affect product availability in sub-Saharan Africa, develop strategies to address these factors, and demonstrate that product availability can be substantially improved at the lowest levels of the supply chain.
1, 2 Although there is limited evidence defining the supply constraints on CCM approaches, some studies have shown that child health programs often suffer shortages of key products, which suggests that supply chain factors may be adversely affecting outcomes of those programs.
The formative research component of the study, described in this paper, assessed the views of pregnant women attending ANC and women who had been pregnant recently as well as the views of health care provider on available ANC services, and supply chain factors hindering the implementation of the ANC model.
To understand how supply chain factors affect product availability at the community level, the Improving Supply Chains for Community Case Management of Pneumonia and Other Common Diseases of Childhood Project developed a theory of change (TOC) framework for gathering, organizing, and interpreting evidence about supply constraints to community case management (CCM).
Druse proteins involved with inflammation and innate immunity (e.g., amyloid-β, immunoglobulin light chains, factor X, C3, C5b-9 complex) have received particular attention because sequence variants in several complement proteins are associated with increased ARM risk [13], [14], [15], [16].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com