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CH: Study design, manuscript preparation and review.
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Here we performed a prospective observational study of the potential beneficial ketogenesis-induced effects on CH, studying a group of consecutive drug-resistant CH patients.
Some of the Swedish CH patients (n = 27) (Department of Neurology, Karolinska University Hospital) were identified from previous CH studies and appropriate data of clinical symptoms were collected from questionnaires.
The limited lateral resolution (on the order of 100 μm) offered by laboratory sources has hindered its extension to the microscopic analysis in CH studies [22].
Genetic studies implicate the HCRT-system in CH; studies show that a particular polymorphism in the HCRT-2 receptor gene may increase the risk of CH [32, 34, 103], although not entirely consistently [35, 104]. .
Recently it was demonstrated in a post hoc analysis of the Chest study that fluid resuscitation with HES versus saline was more favorable when AKI was defined according to the diuresis criterion only, whereas saline was more favorable than HES when AKI was defined according to the creatinine criterion only [ 25].
A full list of all endpoints is provided in the published Pathway CH-1 study [8].
Table 1 Baseline characteristics of patients enrolled in the Pathway CH-1 study [8] Variable Pathway CH-1 (N = 28) Age (years) 45 (20–63) Male gender (no.; %) 278484 %) Baseline CH attacks per day 2.74 (0.57–10).
The results from the multicenter European Pathway CH-1 study indicate that patient-controlled SPG stimulation provides statistically significant CH pain relief and is also associated with a reduction in CH frequency.
First, the Pathway CH-1 study, while randomized and sham-controlled, included only 28 patients.
The Pathway CH-1 study and its findings have been presented elsewhere [8].
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