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They should be useful in early identification of at risk individuals and in designing and monitoring interventions (smoking cessation, exposure reduction, and chemoprevention).
Variables retained in the final model were smoking status, pack-years of smoking, age at smoking cessation, exposure to asbestos or dusts, and history of COPD or hay fever, but not use of mentholated cigarettes.
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Consistent with this, Applebaum et al (2013) observed some evidence that the reduced risk dissipated after 15 years since cessation of exposure, suggesting that the protection from exposure to endotoxin is reduced over time.
Symptoms and pulmonary function abnormalities improved with cessation of exposure and, in one worker, recurred with repeat exposure.
Animals were sacrificed after cessation of exposure and after 50 and 92 d of non-exposure recovery.
According to these authors, the presence of fiberglass in lymph node tissue and resolution of the disease process after cessation of exposure supports the association of this sarcoidosis-like disease and fiberglass exposure.
In particular, occupational studies have documented adverse effects on motor, psychological, and neurological function following long term exposures in adults, with progressively worse symptoms persisting long after cessation of exposure [ 1- 6].
The studies analyzing asbestos lung burden in workers at different intervals following cessation of exposure suggest a linear decrease in concentration over time, that is independent of duration of exposure.
FEV1 level increased significantly with years since cessation of exposure, which suggests that active versus retired work status might be an important confounder or effect modifier of endotoxin exposure.
Complete cessation of exposure leads to the improvement in disease control.
Under this novel model, cessation of exposure could arrest or reverse the carcinogenic process.
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CEO of Professional Science Editing for Scientists @ prosciediting.com