From these representative voxels, the mean metabolite ratios as proposed by Kounelakis et al. were calculated [ 25] over the CE region: NAA/tCho, NAA/sum, tCho/sum, NAA/Cre, Lips/tCho, tCho/Cre, Myo/sum, Cre/sum, Lips/Cre and Glx/sum (10 parameters).
Sea turtles, however, had high numbers of records from the Atlantic CW and CE regions, but gaps in the southern Pacific, Arctic and Antarctic regions (Figure 4d).
We found H3K4me3, H3K27ac and H3K36me3 enrichment in CGIs in CE regions, independently of the evolutionary process involved in their generation.
H3K36me3 was the only mark to be enriched in 3' and intragenic CGIs in CE regions for majority of cell lines; this finding is again intriguing considering that H3K36me3 is reported to be a gene body mark [ 8, 20].
H3K36me3, on the other hand, showed a significant enrichment in global CGIs only in CE regions: this could be due to a small sample size effect (Additional file 2).
Figure 2 XPS spectra of (a) 1.2% Ce-TiO 2 coating and (b) Ce 3d region for 1.2% Ce-TiO 2 coating.
These datasets go back various lengths of time but since 1100 CE, the region is accurately sampled.
After its conquest by Maḥmūd of Ghazna in the 11th century ce, the region was held by various Muslim dynasties.
During the first five centuries ce the region was a part of Tamilakam the territory of the Tamils and thus was sometimes partially controlled by the eastern Pandya and Chola dynasties, as well as by the Cheras.
Designated a county by the emperor Charlemagne about 806 ce, the region was largely ruled from the episcopal see of Chur (Coire), the bishop of which had become a prince of the Holy Roman Empire in 1170.
