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While the situation is somewhat improved by the presence of the antibody, a small number of EBs do still ascend to the upper cervical boundary).
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A major advance in understanding the genetic basis of neurulation has been the finding that initiation of closure at the hindbrain-cervical boundary (Closure 1) requires non-canonical Wnt signalling: the so-called planar cell polarity (PCP) pathway (Fig. 2).
Using the YSQ-1 the children were good at identifying the borders of the cervical spine (both boundaries correctly identified: 91.8%) but the lumbar (67.4%) and thoracic spines (63.3%) were somewhat less clearly recognised (Table 2).
During the interview the children were tested for agreement of the upper and lower boundaries of the cervical, thoracic and lumbar spine between the drawings included in the questionnaire (see Additional file 1) and the interview findings.
The domain illustrated represents the cervical epithelium, oriented with the vaginal boundary at the base.
A pelvic ultrasound was performed and demonstrated a 32 x 25 mm abnormal radiodensity at the anterior uterine wall with an unclear boundary at the anterior cervical wall, concerning for retained products of conception versus placenta accreta.
HScrib localised at the cell cell boundaries in the normal cervical epithelia.
In larger tumors, peripheral edema might obscure the real boundary of the lesion and cervical stroma can be compressed into a thin margin, leading to over- or under-staging[ 24 ].
We performed a small pilot study in our department on 20 women prior to operative hysteroscopy in January 2006 to investigate the preoperative variability (SD) in cervical dilatation, in order to calculate the boundaries needed for the statistical model.
Human scribble showed the cell cell boundary-associated localisation in the cases of cervical condyloma, which is a low-risk HPV-related wart.
The modelled distance L was limited to 30 μm by assigning flux derivatives as zero at the near and far end boundaries as in Eq.4 and resembles the average length of HeLa cervical cancer cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com