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Certificates of analysis for the intervention and placebo preparations were also missing in some cases.
Quinine used in both periods was obtained from a single supplier (Indus Pharma Ltd ,Pakistan) together with their respective certificates of analysis for each batch.
The placebo for zanamivir trials contained lactose powder, which can potentially cause bronchospasm, but certificates of analysis for the intervention/placebo preparations were not available except for one trial.
We also noted several other items that were not included in all full clinical study reports that could introduce other biases: Certificates of analysis for the intervention/placebo preparations Patient enrolment dates explicitly reported (only trial inception and cessation dates are given; in zanamivir trials these are partially redacted) Explicitly reported date of trial unblinding.
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Label as Stock standard B. (b) Obtain loss on drying (important for -catechin hydrate): Crystal water is not stoichiometrically distributed; for -epicatechin loss on drying normally equals 0) and HPLC purity of analyte from supplier's certificate of analysis for each new lot number to calculate purity: Purity = [100 - loss on drying ] * HPLC purity /100.
Thereafter, the correct dilution of anti-pig Ig (M, A, or G) was calculated by substituting the mean positive control OD from the Certificate of Analysis for "y" in Equation 1 and solving for "x".
One of the reasons for the discrepancies between this study and the study by Schantz and co-workers [ 36] could be due to inhomogeneous particle distribution in different bottles of SRM 2975, which the NIST has stated in the certificate of analysis for this material [ 33].
Certificate of analysis from supplier is required for purity correction of each new lot number.
The indictment also described a scheme to fabricate so-called certificates of analysis that accompanied shipments to summarize for customers the results of tests on the products.
Meanwhile, Parnell's brother was apparently forging so-called certificates of analysis that attested to the purity of contaminated lots.
They denied any wrongdoing, saying that two certificates of analysis showed that the suspect shipment was safe, pharmaceutical-grade syrup.
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