We therefore adopted a simple intuitive criterion of parameter certainty: we defined sensitivity for each parameter as the relative increase of the SS when the parameter was perturbed and hold constant (upward and downward with two increments, 1.5 and 2.25 folds).
We were also aware that rare, serious outcomes not in our derivation set would make validating any rule with 100% sensitivity and certainty almost impossible.
The first cutoff allows the practitioner to exclude the diagnosis (fluid responsiveness in the present case) with near-certainty (that is, privilege sensitivity and negative predictive value), whereas the second cutoff is chosen to indicate the value above which the selected diagnosis can be included with near-certainty (that is, privilege specificity and positive predictive value) [ 101].
As 135 patients could not be categorized with certainty ("undetermined") formal calculation of sensitivity and specificity was precluded.
As screening tools continue to advance, our ability to identify women who have or will have cervical precancer will approach certainty and will supersede the sensitivity of colposcopy.
Sensitivity analyses by disease certainty and exposure certainty did not strengthen these results nor did restricting the exposure window to 2 20 years before case diagnosis (Supplementary Table S1).
However, to date, a molecular marker, whose sensitivity can give the certainty either of the presence or the risk of this cancer, has not yet been identified.
Studies have demonstrated that PET MPI with Rb performs superior to SPECT in sensitivity, image quality, interpretive certainty, and diagnostic accuracy [ 38, 39].
The men and women alike were stunning but delicate; they were tofu salad not beefcake, thin not buff, challenging the macho certainty of the 1980s with a certain vegan sensitivity and ambiguity that recalled James Dean.
Typically, the theoretical analytical sensitivity of a given PCR with certainty is approximately 3 copies [39], assuming a Poisson distribution, and a 95% chance that at least 1 copy is detected in the PCR.
