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Without minimizing the need to also improve FAM-MDR's handling of missing data (whether at the genotype or phenotype level), not being able to account for the full complexity of a pedigree is certainly a drawback of PGMDR.
In this context it is certainly a drawback of our study that we did not record the level of preoperative sedation or anxiolysis using clinical measurements on appropriate scales.
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This is certainly a drawback in the prevention of diseases because of the lack of water.
The prediction step added a source of uncertainty to the approach, which was certainly a drawback.
There is a drawback of course.
It is arguably a drawback of Cimate Camp.
Raj Dhonota, a former contestant on The Apprentice, believes this can be a drawback of crowdfunding.
The variability of wind speeds and, hence, of output has been a drawback of wind power.
Each has a drawback, of course.
The largest drawback by far is the illegality, which has not been an inherent drawback of the substance, it's a drawback of public policy.
A drawback of GAMs is their potential for over-fitting.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com