In particular, how certain transcripts are activated/maintained despite suppressed transcription during low body temperatures is poorly understood.
Myc mutants lacking transcriptional activity could up-regulate mRNA cap methylation of certain transcripts, implying that Myc proteins have a relatively direct effect on mRNA cap methylation.
We have demonstrated that SNS accurately captures expression of a majority of cell-type specific and functionally relevant genes in post-mitotic cells, while showing under-representation of certain transcripts related to cellular physiology that may be more rapidly exported from the nucleus25.
The recruitment of enolase by the RNA degradosome has been implicated in the turnover of certain transcripts, and it is mediated by a small segment of roughly a dozen residues that lie within a natively unstructured sub-domain of RNase E. Here, we present the crystal structure of enolase in complex with its recognition site from RNase E at 1.6 Å resolution.
Certain transcripts could escape cleavages due to the absence of intronic miRNA binding sites within these sequences.
Certain transcripts correspond to multiple probe sets on the Affymetrix array.
5) Alternative editing can change the UTR sequence and thereby might affect regulation of expression or stability of certain transcripts (COXIII-K12, A6-D08).
By using the information gleaned from the sour-ageusics, we recognize that we are drawing conclusions based on the inability to detect certain transcripts – i.e. "negative data".
Nevertheless, without further experiments on stability of certain transcripts, we cannot exclude the possibility that findings reported here may (at least in part) be due to alterations in the stability of individual transcripts.
This apparent discrepancy was due to the overabundance of certain transcripts that were similar to a few proteins from filamentous fungi in the EST database, whereas these were collapsed into single genes in the unigene set.
The SDF-1 receptor, CXCR4, was undetectable or minimally expressed in undifferentiated hESC, although it should be noted that the form of MPSS used at that time failed to detect certain transcripts such as human TH [30].
