This type of interaction may allow a wider range of peptides to be pumped into the ER and in turn be presented by class I. Second, the TAP genes may interact in a specific manner, and may pump peptides for binding to specific class I genes or only in certain tissues, increasing the specificity of peptides pumped into the ER.
The amino acid positions which vary only in certain subgroups and alter the specificity of a protein are called the Specificity determining positions (SDP's).
I hadn't done any kind of formal dancing since the age of 18, and it was incredible to pay attention suddenly to the specificity of certain muscles and movements, to recognise the exactitude in the bodies of the company dancers as they glided and darted through the space.
Wherever you are, there is likely to be a certain level of concern about the specificity of guidance and the risk of grievance.
It may also reflect the specificity of certain microRNAs in rare human prion diseases that was recently reported [ 50].
The immune response depends on certain bacterial factors, such as the specificity of LPS/LOS and patient-related/host factors.
The specificity of certain plant response to AHLs has led some to hypothesize that an AHL receptor exists in plant systems; indeed, recent reports suggest that G-protein coupled receptors may be required for AHL response in A. thaliana.
Inter-species variations in test outcomes are due in part to the specificity of certain reagents included in commercial kits; for example, the labelled secondary antibodies or conjugates may have varying capacity to bind immunoglobulin G (IgG) from different species [ 4].
Although concern has been raised over the specificity of certain commercially available antibodies directed against epitopes in the α7 nAChR subunit (Herber et al., 2004; Moser et al., 2007), our non-commercially produced antibody was well characterised by ELISA and Western blot analysis.
With respect to figure 6, we have updated the Figure 6 title to "Simplified schematic of one possible path of kinase network evolution" to make it clear that we are simply exemplifying our discussion with a visual example that helps the reader think about the experiment in Figure 5 where we know for certain that we have expanded the specificity of the extant Ime2 kinase.
