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NAFLD is common in the population and in certain sub groups (e.g. type 2 diabetes) up to 70% of patients may be affected.
The effect sizes from these small studies may be due to ESWT being beneficial in certain sub groups within the population (e.g. runners), or may be as a result of a failure to blind the participants successfully to their treatment allocation, as previously reported by one of the authors [ 30].
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In contrast, population-based modelling approaches (e.g., Bosse et al. 2011) do not distinguish individual agents, but instead describe the dynamics of crime in terms of mathematical formulae (mostly differential equations) over variables that represent the densities of certain sub-groups in the population.
For DIF in particular, the Rasch model identifies items for which being a member of a certain sub-group of test-takers affects the probability of endorsement of that item when compared to other groups.
"There's a real underestimation of the audience happening people see it as a false dichotomy," where editors believe they are forced to choose between catering to certain sub-groups within the LGBTQ umbrella over others.
It is possible that certain sub-groups in the trial would benefit more or less from a particular treatment.
Clustering of co-expression data revealed that although almost all lumen protein genes share a high level of co-expression, certain sub-groups could be identified.
Undoubtedly, the lifestyle intervention that was offered does not meet the needs of certain sub-groups.
While the majority heal uneventfully, certain sub-groups would benefit from strategies to accelerate healing.
Hence, it cannot be excluded that certain sub-groups might benefit from cholecalciferol supplementation.
Other published research has found that cut-points lower than those recommended are optimal for certain sub-groups [ 27- 29].
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