Thus whilst protein protein interactions may be considered difficult targets for small-molecule inhibitors, this cannot be generalised, and certain interactions with shared features in terms of the binding site appear to be more amenable to small-molecule inhibition than others.
In spite of certain shared molecular features of replicative and chronological aging in yeast (Kaeberlein 2010; Longo et al. 2012) and the rDNA instability-based model of replicative aging (Sinclair and Guarente 1997), CA-mediated changes in nucleolar architecture and activity have not been investigated.
By pharmacophore analysis, certain PXRs share similar features such as human, mouse, and rat PXRs, suggesting overlap of function and perhaps common evolutionary forces.
Or, gut bacteria in humans have evolved a generalized mechanism for detecting certain features shared by all antibiotics—including the synthetic ones designed by scientists—and so can mount a defense against new threats.
These species all shared certain features: small grain size (and thus greater buoyancy in air), high pollen production and considerable abundance.
At the same time, both shared certain features, such as the unique design of the shoulder girdle where the clavicles are located medial to the scapula.
The phenotypes in families with INF2 mutations shared certain features.
These models (1, 4, 5 ) shared certain features.
On one understanding frequent among philosophers, consciousness is a certain feature shared by sense-experience and imagery, perhaps belonging also to a broad range of other mental phenomena (e.g., episodic thought, memory, and emotion).
While the specifics of the recent high-profile cases varied, many shared certain common features.
He eventually turned these thoughts into a paper on "Classical Empiricism", published in 1970, in which he argued that empiricism shared certain problematic features with protestantism.
