Thus, increased peripheral NGF levels lead to increased production and release of BDNF from the central synapses of nociceptors in the spinal cord, and this may be critical for certain central sensitization events, especially those involving N-methyl d-aspartate (NMDA) receptors (Kerr et al., 1999).
The fraction of surface intergranular sites corroded and intergranular surface cluster length increased sharply at a certain degree of sensitization.
In most cases, agranulocytosis appears to develop as a result of sensitization to certain drugs and chemicals; infection then follows as a consequence, not a cause, of the profound neutropenia.
Of course, these differences reflect the intrinsic capacity of certain occupation agents to induce sensitization but equally on the conditions of exposure and the different methods of evaluation, which depend on the study design.
NK cells have the capacity to kill certain tumour cells without prior sensitization [11], control tumour growth in vivo and prevent the dissemination of tumours [12].
The very high percentage of drugsellers answering that antibiotics can be used to treat STI might to a certain extent be due to sensitization as STI was one of the topics of the intervention although the teaching had not yet started.
Our results show that, despite sharing certain aspects with UVB-mediated TRAIL sensitization, the synergism of cisplatin-induced TRAIL sensitization of melanoma cells is less pronounced, at least in 2D cell culture.
There are experimental results suggesting the role of PACAP in the development of peripheral sensitization as well in certain models of pain [78].
The sensitization was attributed to certain interneurons presumably located in an extrinsic "state" system that was directly activated by the primary stimulus [ 10, 11].
Several lines of evidence support a similar role for human isocyanate skin exposure, namely, that such exposure occurs and can contribute to the development of isocyanate asthma in certain settings, presumably by inducing systemic sensitization.
