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The positive feed-forward loops between EGFR, target of gefitinib and KRT8 enable gefitinib to amplify its effect and dominate the synergism, whereas certain negative feedback loops between BCL2, target of docetaxel and KRT8 reduce its contribution to the synergism.
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Developers are responsible for making sure that negative feedback from users (in the form of 'Hides') doesn't break above certain limits.
Simulations of our ubiquitination-phosphorylation cascade model demonstrate that above certain threshold strength of negative feedback, motif 4 displays sustained oscillations of network species, e.g. active E3 (E3*) or active S (S* + pS*) (shown in Figure 6b).
I'm getting a lot of negative feedback from certain corporate people.
Inhibition of oncoproteins or certain effector pathways might reduce negative feedback and actually increase signal output, as shown recently in BRAF mutant colon cancer (Prahallad et al, 2012).
In other words, there is an age-related loss of sensitivity by the hypothalamus to the negative feedback of certain hormones, such as estrogens and glucocorticoids [ 6- 13].
These autoreceptors are located on presynaptic neurons and serve to regulate neurotransmitter release by activating negative feedback loops when neurotransmitter concentrations in the synaptic cleft reach certain levels.
These are given by combinations of certain TF concentrations, resulting from the dynamics of the interaction network, which contains several positive and negative feedback loops.
When the amounts of positive feedback (amplification) and negative feedback (suppression) are balanced, stable behaviors such as oscillations in the values of certain components of the system can emerge [13].
Despite the negative feedback, he persevered.
NNF: Negative feedback loop with additional negative feedback loop.
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