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In addition, certain mutations at the ribosomal 23S RNA can cause resistance to macrolides.
We can speculate that certain mutations at site 211 disrupt the structure of the 195 212 alphahelix thus contributing to resistance.
A computational method called 'correlated mutation analysis' searches for pairs of positions in the alignment that display co-variation, i.e. where particular mutations at one position tend to be accompanied by certain mutations at the second position.
Hence, our finding that phosphorylation or certain mutations at Y1065 also impair actin bundling is not surprising given the importance of the C-terminal hairpin in actin-induced Vt self-association; however, we were surprised by the varying degrees of bundling efficiency exhibited by the different Y1065 mutations.
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More specifically, certain mutations occur at a very high frequency in some tumors but are rare in others.
This may be due to the complexities of dealing with a mixture of multiple cell types, or embryonic lethality of certain mutations preventing analysis at an appropriate stage.
At the allelic level, certain mutations are associated with more severe disease phenotype than others [ 10].
It is highly conceivable that certain mutations may be associated with higher risks of cancer at certain sites, as seen with BRCA2 (The Breast Cancer Linkage Consortium 1999; Murphy et al, 2002).
Genetic testing involves looking at a person's DNA to see if certain mutations are present.
The bird may fight off some viruses, ones with certain mutations.
People who carry certain mutations in the gene nearly always develop dementia.
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