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However, the loss of histotypic architecture and phenotypic gene expression combined with the absence of other relevant cell types and dynamic flow makes it a poor choice for certain types of toxicity testing and identification of certain modes of action.
However, it is clear that for chemicals with certain modes of action, these "assessment factors" are often inadequate, as species sensitivity distributions can cover from 2 to > 5 orders of magnitude (Escher and Hermens 2002).
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"We can program the pill to do a certain mode of action based on this change of pH," Dr. van der Schaar said.
In this study drivers are specified as a combination of incentives and capacities to pursue a certain mode of action such as work.
In this process, the metabolite changes are assessed with respect to the strength of the change, the biochemical importance for a certain mode of action, and similarity of metabolite changes having biomarker character.
Subsequently, mode-of-action and pharmacokinetic information were incorporated.
Mode-of-action models strengthen science in two important ways.
Secondly, the similarity of the metabolite changes as well as their quality and importance for a certain toxicological mode of action is evaluated by an expert panel of experienced toxicologists to determine what may be described as "confirmed" matches.
Technics exists within a certain mode of production as well as in certain relations of production.
Torture will always imply a certain mode of brutality.
Hence, the representation of certain pesticide usage classes, modes of action and test species combinations in the reviewed studies [14, 15] may have considerably influenced the degree and frequency of detected deviations from CA prediction in both directions.
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