Collectively, the data suggest that activity among the pro-survival Bcl-2 family members is, in certain settings, functionally redundant, and that tumor cells utilize multiple Bcl-2 family members for survival and proliferation.
Importantly, phylogenetic conservation in the 13 species suggests that certain features are functionally significant and are therefore subject to selection.
Integrating this data with biological information, we discovered that certain groups of functionally related genes exhibit mRNA-protein discordance in a similar fashion.
However, this view has been challenged by new evidences, which demonstrate that certain pseudogenes are functionally active [ 1, 2].
However, in the ~180 Million Years (MY) of independent evolution [ 2], it is possible that certain proteins have functionally diverged.
Even in the few cases where pituitary genes changed, it is not certain these are functionally relevant changes, since serum LH, FSH, or E2 levels are not reported.
Only certain miRNAs have been functionally characterized in the interaction of rice plants with the fungal pathogen M. oryzae or during infection with viral pathogens.
To the Editor: There is evidence that certain brain areas are functionally altered in obesity.
Moreover, all families that are expanded in certain pathogens could be functionally linked to the specificities of the host-fungus interaction.
