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PI3Kγ−/− mice (lacking the catalytic subunit p110) are viable and in certain experimental settings exhibit reduced inflammation [8], [9] as the PI3Kγ pathway controls migration of inflammatory cells [10].
Prediction performance as well as true interactions may be specific to certain experimental settings.
In addition, these constructed "truth" samples often contain large target gene variances that may not represent the subtle changes examined in certain experimental settings.
However, although liver functions after transplantation of such cells into rodents could be improved in certain experimental settings, their functional characteristics were limited in most cases.
For example, phagocytosis is Dectin-1-dependent, and although the TLRs have been demonstrated to regulate phagosomal maturation in certain experimental settings, TLR2−/− macrophages showed no defect in their internalisation of zymosan 46.
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In many experimental settings, one is tasked with obtaining information about certain relationships by applying perturbations to a set of independent variables and noting the changes in the set of dependent ones.
In the same vein, lysosomal organelles have been analyzed in different experimental settings, precisely devoted to the understanding of how certain lysosomal cysteinyl proteases, e.g. cathepsins, can contribute to the cross talk between endolysosomes and mitochondria during apoptosis.
You've spent many years demonstrating that in experimental settings.
Further studies are required to assess the difference between those two different experimental settings.
Supplementary Table S1 summarizes the experimental settings of the 16 batteries.
But young people appear to be discovering the visceral experience of classical music, especially in experimental settings like the Miller Theater.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com