Sentence examples for certain excipients from inspiring English sources

However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics.

The thermal stability of the toxoids on the surface of Alhydrogel® was monitored with DSC and also showed significant improvement in the presence of certain excipients.

Furthermore, as indicated in Table 2, certain excipients exhibit biological activity by inhibiting metabolic enzymes in the gut wall and intestinal efflux pumps (Constantinides et al. 2007; Chen 2008).

The screening and careful selection of excipients is a critical step in paediatric formulation development as certain excipients acceptable in adult formulations, may not be appropriate for paediatric use.

Hence, QS-21 is associated with injection pain in simple buffer formulations, but it is possible to improve the acceptability of QS-21-containing formulations through reformulation with certain excipients.

The correlations between the fractal parameters and the properties of the excipients, including brittle fracture and indentation hardness, gave plausible explanations for the similarities between certain excipients, supporting a phenomenological understanding of the behavior of excipient compacts and their surfaces.

Other studies have focused on formulation based comparisons where certain extended release excipients have been shown to be more vulnerable to dose dumping than others.

Thus, ostensibly unreactive excipients under certain conditions may increase heterogeneity and acidic species in formulated recombinant monoclonal antibodies.

At dissolution, the acid excipient develops certain mechanisms, based on local pH modifications of the medium, which strongly influence drug release.

In the histogram of ebastine, it was difficult to clearly distinguish ebastine from the excipients in a certain domain.

Further, Gelucire 39/01, being highly lipophilic excipient, confers a certain degree of hydrophobicity to the emulgels which retarded the rapid penetration of dissolution fluid inside the emulsion structure, thus, increased buoyancy lag time.