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Riboflavin at high doses (400 mg) showed a certain efficacy in preventing migraine, with few side effects (moderate abdominal pain, diarrhoea), in one RCT [174].
The drug is mainly used for the treatment of viral hepatitis, hepatic fibrosis, and arrhythmia, but it also has certain efficacy in the prevention and treatment of tumors (Zhang et al., 2001; Zhang et al., 2011; Liu et al., 2014).
The most visible disadvantage is the high attrition rate (about 90%) of potential compounds at the late stage of clinical trials due to certain efficacy and clinical safety problems (Nwaka and Hudson 2006).
Pizotifen (1 4 mg/day), in a dated double-blind study, showed a certain efficacy in a limited number of patients with episodic CH (reduction >50%% of attack frequency in 36%% of the cases and interruption of cluster period in 21 %) [289].
Sartre describes him as being torn between two kinds of morality: one of limited scope but certain efficacy, personal devotion to his mother; the other of much wider scope but uncertain efficacy, attempting to contribute to the defeat of an unjust aggressor.
In this work, the principles of a bibliographic search, the steps that must be followed for the design and development of the phases of a strategy of bibliographic search, and the main functionalities of MEDLINE needed for any biomedical professional to initiate and develop a bibliographic search with certain efficacy are briefly explained.
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In clinical applications, it has been found that BA preparation has certain clinical efficacy on endotoxemic cirrhotic patients, and basic researches also confirmed that BA extracts could protect liver cells and had anti-endotoxin function [ 16, 17].
Although a number of chemotherapeutic drugs are available for the treatment of cancer, which can be used for controlling the growth of cancer and have received certain curative efficacy, the side effects limit their application.
Even when the validity of using certain scales as efficacy endpoint measurements has been criticized [ 86, 87], these and other efficacy endpoints such as good symptomatic control, improved QoL, and reduced hospitalization rates seem to be consistently achieved by patients with schizophrenia treated with LAIs.
Although MSC-based therapies have been shown to be safe and effective to a certain degree, the efficacy remains low in most cases when MSC are applied alone.
Despite clinical treatments for adipose tissue defects, in particular breast tissue reconstruction, have certain grades of efficacy, many drawbacks are still affecting the long-term survival of new formed fat tissue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com