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Remarkably, MCMJR1 displays a certain degree of specificity towards the TMD region of the substrates.
A similar effect was found previously for celecoxib, another inhibitor with a certain degree of specificity for COX-2 [ 6].
These analyses showed that HATs exert a certain degree of specificity for particular lysine residues on different histone tails.
Still, carprofen seems to possess a certain degree of specificity for COX-2, although it may vary between species.
In comparison, the total number of cysteine peptidase genes from the same peptidase family of rice and Arabidopsis is high (88 candidate genes in both species) pointing to a certain degree of specificity of the newly assembled contigs for remobilisation.
We have chosen the protein decoy path because, if a certain degree of specificity can be assumed between a chemokine and its GAG ligand [ 25], CXCL8 should have a built-in specificity for its GAG ligand.
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All three mischarging mutant enzymes still retain a certain degree of tRNA specificity; in vivo they acylate supE glutaminyl tRNA (tRNA(Gln] and supF tRNA Tyr) but not a number of other suppressor tRNA's.
Thirdly, the expression patterns of two nDNA-encoded genes, NDUFA4 and NDUFA5, notably diverged from the rest of the nDNA-encoded subunits, suggesting a certain degree of tissue specificity.
Several MgCRP-I displayed, at least to some extent, a certain degree of tissue specificity (fig. 6).
In this respect, promiscuous ARTs resemble certain protein kinases which are promiscuous toward a wide range of artificial substrates, but nevertheless exhibit a certain degree of target specificity in vivo (Woodgett et al. 1986).
There are important differences between the mechanisms controlling the increase of β-cell mass observed during pregnancy and obesity suggesting certain degree of etiopathogenic specificity on the mechanisms controlling β-cell mass expansion [ 12- 15].
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