Since he has been in office, President George W. Bush has decided to limit federal funding of stem cell research to certain "cell lines" that already exist.
Curiously, certain cell lines can faithfully propagate different prion strains, while other cell lines are permissive to only one strain28, 29.
Complexes which had strong DNA interactions in the binding studies have proven to be the most efficacious against certain cell lines.
Among them, two compounds (1h and 1i) are the most representatives demonstrating not only high growth-inhibitory activities against some leukemia cancer cells, but also fairly good activities against the growth of certain cell lines of some solid tumors.
The potency and selectivity demonstrated by these compounds are dependent on the cancer cell line, where the following compounds were found the most promising agents against certain cell lines: compounds 1i and 1j for HL-60 cells, 1a and 1b on HCT116 cells, 1f on Hela cells and 2h on H1975 cells.
Interestingly, σ2 expression was found to be higher than σ1 expression in certain cell lines [27, 33, 34].
Tumor necrosis factor (TNF) is a growth-modulatory cytokine that inhibits the growth of certain cell lines, stimulates the growth of some, and has no effect on the growth of still others.
A few compounds appear to be more active against certain cell lines (e.g., 7, 13 and 15 more active against MCF-7 cells, 16 more active against A549 cells, and 10 more active against HeLa cells).
In proposed rules released this month, the National Institutes of Health is a bit more restrictive, prohibiting researchers from using federal funds to derive cell lines from an embryo but allowing them to work with certain cell lines created using private funds (ScienceNOW, 1 December).
Within certain cell lines, some clones display high levels of methylation, whereas other have very few to no methylated CpGs.
Riluzole, an ion channel modulator, has been shown to demonstrate by estrogen receptor stress an inhibition of DNA synthesis and apoptosis in certain cell lines [33].
