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In lesser hands, the approach might feel haphazard, but Uglow's deep knowledge of the period reveals certain binding themes.
Lastly, it is possible to design intrabodies to block certain binding interactions of a particular target molecule, while sparing others.
The clinical efficacy of antipsychotic drugs has been associated with a certain binding profile for a set of G protein-coupled receptors (GPCR s.
However, competition experiments revealed certain binding preferences (Supporting Information S1).
However, not all biological targets are druggable since only certain binding sites are complementary to drug-like compounds in terms of physicochemical properties (i.e. size, shape, polar interactions and hydrophobicity) [1], [2].
First, MeCP2 favors certain binding sites in vitro [32], but changing the ratio of protein, probe, and non-specific competitor can easily reveal binding to suboptimal sites; placing multiple CpGs on a probe also easily overrides the sequence specificity.
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Binding of certain chromatin binding proteins and the post-translational modifications on histones are the major determinant of functionality of regulatory sequences [ 2, 25, 26].
This ion implantation approach provides a useful strategy to attach AuNPs on the ITO surface with higher density without using certain organic binding molecules.
Cranston said he felt certain that binding legislation would pass the Senate this year.
Next, we wanted to explain why certain TF binding events are functional whereas others are not.
7) Results section" The term 'helix-turn-helix motif' is defined as an architecture in certain DNA binding proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com