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Cerebellar parenchyma included in the surgical specimen did not reveal any preexisting malformative anomaly.
Traumatic birth-related intracranial hemorrhages can occur both into the extra-axial spaces [epidural (Fig. 6b,c), subdural (Fig. 8a-c) and subarachnoid (Fig. 9a,b)] and within the cerebral or cerebellar parenchyma (Fig. 10a-d) (ESM_4).
To this end, we injected viral particles that carried Grid-2 and GFP cDNA into the cerebellar parenchyma of adult mice.
Since rabbits have a longer lifespan than rodents, the protracted neurogenesis within its cerebellar parenchyma could be a suitable model for studying adult nervous tissue permissiveness in mammals.
The results obtained in slices were confirmed in vivo by chronic infusion of EphA4/Fc or ephrin Fc fusion proteins into the intact cerebellar parenchyma of adult mice.
In a first group of mice, we administered the sodium channel blocker tetrodotoxin for 6 days through a minipump inserted in the cerebellar parenchyma in order to block the repressive action of climbing fibres on spinogenesis [24], [25].
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No abnormalities of brain parenchyma, parenchymal cerebellar or brainstem were found.
Figure 2 Presence of multiple small enhancing lesions scattered rosette in the brain parenchyma and cerebellar predominant in regions of the basal ganglia and the cerebral cortex, in favor of small abscesses formations.
The E-group's proportion of cerebellar volume to total parenchyma was comparable to that of a large normative comparison group while the C-group's was significantly smaller [ 79].
Brain parenchyma of both cerebellar and cerebral hemispheres was invaded by the tumor cells directly or through the perivascular space.
Normative data [ 97] for a healthy sample (n = 433) of children from 4 to 18 years of age indicated mean cerebellar volumes of 132.82 cm, which corresponded to 10.52% of brain parenchyma, comparable to the 10.55% found for the IUGR sample's E-group while the IUGR C-group's cerebellar volume was only 9.88%, a significant difference (p = 0.04).
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