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We expected this to reduce the proportion of patients with the cerebellar form of MSA (MSA-C) in our cohort, but cerebellar features were noted at presentation in 20% of our patients, similar to the findings of a prospective study (Schrag et al., 2008).
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"Cerebellar forms" were considered when a patient presented dysarthria and ataxia.
To test a second, non-cerebellar form of learning, we subjected three of our models to initial acquisition of a water Y-maze.
The major (1.7 kb) and minor (1.5 kb) cerebellar splice forms were not previously resolved in Northern blots [17], presumably because of the difference in abundance, and the effect of polyA tail heterogeneity (with an expected mean length of 250 adenosines, [41]. This shorter isoform was not detected in the embryonic retina (Figure S3d).
The cerebellum develops in the mouse from embryonic day 9 (E9) with the cerebellar anlage forming from the roof (the alar plates) of the metencephalon.
Cerebellar regions also form well-localized bilateral activity patterns as shown in Fig. 6.
In contrast, many parallel fibres (which are the axons of cerebellar granule cells) form synapses with the spines of the distal dendritic compartment of a Purkinje cell.
In mice, GNPs are derived from the rhombic lip region of the fourth ventricle prior to embryonic day 14.5 and migrate dorsally over the cerebellar primordium to form the nascent external granular layer (EGL) [3].
How this information is represented in and transmitted by upstream neurons in the circuit, in particular in cerebellar granule cells which form the input layer of the cerebellar cortex remains unknown.
In sheep, brain malformations, mainly cerebellar hypoplasia and forms of hydrocephalus, are frequently due to in utero viral infections.
The cerebellar Purkinje cell forms space-filling dendrites that extensively ramify non-overlapping branchlets in a single parasagittal plane (Ramon y Cajal, 1911).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com