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This difference could be due to both the small sample size of this German study without randomization and to the existence of a clear, binding NSM protocol in the RCT, according to centres practice, whereas in real-life NSM treatments are less standardized.
Although some form of peer review currently exists within all surveyed cancer centres, practice variation suggests potential variation in the quality of the peer-review processes.
In all four centres practice is based on guidelines formulated by the Scottish Office Home and Health Department (1998) and incorporated into Scottish Intercollegiate guidelines Network (SIGN) Guideline 29, 1998.
However, significant inter-centre differences should not exist in the time taken to activate suitable patients for transplantation or in receipt of a transplant once on the waiting list, especially for transplantation from donors after cardiac death or living kidney donors, as centres' practice patterns are predominantly responsible for these outcomes.
Similar(56)
The phenomenon of clustering emerges when outcomes observed from patients managed by the same centre, practice or physician are more similar than outcomes from different centres, practices or physicians.
Prophylactic fluconazole may be a worthwhile alternative to mould-active prophylaxis in alloHCT in centres practicing early diagnostics-driven therapy [ 8].
11 Although general guidelines for the assessment of patients' suitability for transplantation are available, individual clinicians' and centres' practices may vary in the interpretation of these guidelines.
It was described in the mid 2000 [ 16, 50– 53], in centres practicing MRI before biopsies, having also a good experience in TRUS imaging.
Inter-centre differences were more pronounced for access to transplants from donors after cardiac death and living kidney donors and the time taken to activate patients on the transplant list, outcomes that are often predominantly influenced by individual centres' practices and policies.
Few studies examine within centre practice variations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com