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Response was centrally confirmed in the setting of the referenced trials.
Eligible patients had centrally confirmed HER2-positive, surgically resected, invasive breast cancer.
HER2 testing was centrally confirmed or performed in approved reference laboratories.
Figure 1 shows the hazard of recurrence for centrally confirmed HER2+ placebo patients.
Both criteria of disease progression and dose intensity were retrospectively centrally confirmed.
The histologic type was centrally confirmed as SCC in 53 cases (31%) and adenocarcinoma in 118 cases (69%).
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In addition to the local biopsy reading in each centre, biopsies will be re-evaluated centrally to confirm the interpretation of the biopsy.
Results from ELISA assays (for women) and HIV RNA assays (for infants) were confirmed centrally.
Histological diagnosis was confirmed centrally by a pathologist (H.K .. H441, C829, C32, PC-3, H1838 and H2347 were purchased from ATCC.
Biochemical data demonstrating significant reduction in biomarkers of regeneration/myogenic differentiation, linked to significant reduction centrally nucleated fibres, confirmed reduced fibre regeneration after treatment with SMT022357.
All responses were centrally reviewed and confirmed by a panel of experts convened by GFPC Groupe Français de Pneumo-Cancérologiee). Patients were monitored for adverse events, biological abnormalities, vital signs and electrocardiographic changes using NCI-CTC version 2.0.
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