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In brief, all of these interviewees favored local over centralized reviews.
The center's tasks include performing centralized reviews, providing second opinions on difficult cases, and developing new diagnostic tools and training.
Many of these IRBs had had experience with the centralized reviews of the NCI for adult oncology trials, and of the Pediatric Oncology Group, and of for-profit IRBs, and felt that the nature and outcome of centralized IRBs can vary, depending on who happens to be members of the committee.
These interviewees' beliefs and perceptions of the advantages and disadvantages of local vs. centralized reviews are not necessarily objectively "accurate" and/or always justified, but are nonetheless important, shedding light on difficulties that emerge, and will no doubt continue to do so, in attempts to alter the status quo.
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institutions should work out inter-institutional arrangements to deal with privacy issues either through delegated or centralized review; and ix.
Centralized review of past cases by haematopathologists would improve the quality of this data, but is unrealistic in population-based registry data.
To deal with a massive uptick in filings for 501(c)(4) social welfare status in the last few years, the IRS had centralized its review of those seeking such tax-exempt status in a Cincinnati office.
However, in those studies, centralized slide review was not performed.
Reported adjuvant trials used centralized laboratory review because of the high rate of discordant interpretations among individual laboratories [ 30, 31].
For example, large scale centralized pathology review of breast and other cancers occurring in kConFab participants is beyond the scope of current core activities.
These statistics are preliminary since centralized pathology review is ongoing and grade is missing for a large number of the subjects.> The mean age at diagnosis (based on the date of the pathology report)/age at interview of the cases and controls, respectively, was 57.4 years (SD = 11.2 years) and 54.1 years (SD = 11.8 years) (p < 0.0001), respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com