Sentence examples for centrality of target from inspiring English sources

In this context, a recent concept is that essentiality and centrality of target proteins may also increase the likelihood of adverse drug side effects, which in turn may help in progression of diseases among individuals (Wang, Thijssen, et al. 2013).

Table 1 Top potential compounds for inhibition of platelet aggregation according to degree centrality of drug-target network Rank Compound Degree CAS NO.

Computational analysis of network-descriptive metrics (such as 'degree' and 'betweenness') raised striking observations regarding the centrality of viral targets in the context of the human protein network.

However, because of the functional centrality of these targets and their large impact on protein network architecture and robustness we can anticipate that drug designed on this rational could generate molecules with high toxicity.

Based on a disease-specific PPI network, a heuristic synergy score can be calculated based on the topology connection and centrality of drug targets to predict the possible synergy degree.

We show an example where the robustness of an SEN's ecological properties to node and link loss depends on the centrality of the nodes targeted.

Cytoscape 2.8.3 [48] was adopted to draw the DTN and calculate the degree and betweenness centrality of each node (compound or target).

Further, we performed a degree centrality analysis of the GRNs that showed that the degree centrality of the genes allow to target promising mediators of cancer related cellular activities and signaling processes.

where ({chi _{2}^{2}} ) denotes the chi-square distribution whose DOF is 2. In case of target present, the non-centrality parameter is 2|α|2 s H R −1 s.

In case of target present, a method for comparing detection performance of radar systems is proposed by evaluating its non-centrality parameter.

The collection also addresses the centrality of the body to political and cultural activity, targeting the role and constitution of norms in the regulation of bodies, and the construction of spaces that bodies inhabit, in constructing national and cultural identities.